Raw Material 2521-07-5 99% Pure 9-Methyl-9H-beta-carboline/9-ME-BC CAS NO.2521-07-5

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Product name:9-Methyl-9H-beta-carboline
Other name:9-methyl-9H-pyrido[3,4-b]indole;9-Methyl-9H-pyrido[3,4-b]indole;9-Methyl-9H-β-carboline
CAS:2521-07-5
Molecular Formula:C12H10N2
Formula Weight:182.2212
Purity:99%
Appearance:Light yellow solid
Package:1kg/bag
Usage: nootropics

What is 9-Methyl-9H-beta-carboline (9-ME-BC)

9-Me-BC or 9-Methyl-β-carboline is a novel, dopaminergic , cognitive enhancer. It has been shown to improve DA (dopamine, a neurotranmittter vital to mood, focus, vigilance and wakefulness) by inducing growth of hippocampal dopaminergic neurons. The hippocampus, by the way, is the locus of short term memory formation and storage. In addition, 9-Me-BC also has some anti-inflammatory effects. 9-Methyl-9B-Carboline is a dopaminergic enhancer. It operates primarily thorugh up-modulation, differentiation and a protective effect on dendrities and synapses all the while improving dopamine synthesis tasks.

9-Methyl-9H-beta-carboline(9-ME-BC) Benefit:

β-Carbolines (BCs) belong to the heterogenous family of carbolines, which have been found exogenously, that is, in various fruits, meats, tobacco smoke, alcohol and coffee, but also endogenously, that is, blood, brain and CSF.
These exogenous and endogenous BCs and some of their metabolites can exert neurotoxic effects, however, an unexpected stimulatory effect of 9-methyl-β-carboline (9-me-BC) on dopaminergic neurons in primary mesencephalic cultures was recently discovered. The aim of the present study was to extend our knowledge on the stimulatory effects of 9-me-BC and to test the hypothesis that 9-me-BC may act as a  cognitiveenhancer. We found that 10 days (but not 5 days) of pharmacological treatment with 9-me-BC (i) improves spatial learning in the radial maze, (ii) elevates dopamine levels in the hippocampal formation, and (iii) results after 10 days of treatment in elongated, more complex dendritic trees and higher spine numbers on granule neurons in the dentate gyrus of 9-me-BC-treated rats.
Our results demonstrate that beyond its neuroprotective/neurorestorative and anti-inflammatory effects, 9-me-BC acts as a
cognitive enhancer in a hippocampus-dependent task, and that the behavioral effects may be associated with a stimulatory impact on hippocampal dopamine levels and dendritic and synaptic proliferation.