Factory Price API 99% Quinine 130-95-0 GMP Manufacturer CAS NO.130-95-0

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English name Quinine
CAS No. 130-95-0
Molecular weight 324.417
Density 1.2±0.1 g/cm3
Boiling point 495.9±40.0 °C at 760 mmHg
Molecular formula C20H24N2O2
Melting point 176-177ºC
Flash point 253.7±27.3 °C

Quinine is a quinoline derivative, which can combine with the DNA of Plasmodium to form a complex, inhibit the replication of DNA and the transcription of RNA, thereby inhibiting the protein synthesis of the parasite, and its effect is weaker than that of chloroquine. In addition, quinine can reduce the oxygen consumption of Plasmodium, inhibit the phosphorylase in Plasmodium and interfere with its sugar metabolism. Quinine also causes malaria pigment agglutination, but it develops slowly, rarely forms large clumps, and is often accompanied by cell death.

Electron microscope observation showed that the nucleus and outer membrane of the protozoa were swollen and had small vacuoles, and blood cell granules aggregated in the small vacuoles, which was different from the pigment agglutination of chloroquine. In blood, certain concentrations of quinine can cause premature rupture of parasitized red blood cells, thereby preventing schizont maturation. Quinine has no effect on the infrared stage and cannot cure benign malaria. Long-term treatment can cure malignant disease, but it has no direct effect on the gametophyte of falciparum malaria, so it cannot interrupt the transmission. Quinine has an inhibitory effect on the heart, prolongs the refractory period, slows conduction, and weakens its contractility. It has a weak excitatory effect on the pregnant uterus.

Quinine is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633.

Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose.

Quinine was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. emeraldgo(at)hotmail.com.

Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels.

The mechanisms of its antimalarial effects are not well understood.